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Metformin-induced AMPK activation significantly improved renal autophagy, inhibited EMT of renal TECs, reduced tubulointerstitial fibrosis and delayed the onset of DKD (144)

INSR B -IGF1R hybrids comprises up to 30% of INSR and IGF-I receptors in muscle due to high expression of both and this hybrid predominantly responds to IGF-I (less to insulin) and explains the important role of IGF-I in growth and metabolism in skeletal muscle

doi: 10.1021/acsami.0c10282 146 SwilamNNematallahKA

LY: Writing review & editing, Conceptualization

Therefore, in order to contextualize the complexity of the metabolic network and the impact of Gclc on it, we analyzed our transcriptomic data using Compass, a flux balance analysis-based approach that allows the characterization and interpretation of metabolic diversity at the single cell level 70,71